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Does spironolactone make you gain or lose weight? Spironolactone will cause the elimination of water from the body causing weight loss, but it does not cause fat loss directly, according to Dr. Seltzer. Losing body water is not the same as losing body fat through healthy nutrition and exercise. In some cases, taking spironolactone might result in the loss of body fat. Is Trulicity covered by insurance? Trulicity is covered by most Medicare and insurance plans. Are antidepressants bad for your kidneys? Q: Are antidepressants harmful to people with chronic kidney damage? A: Any medication, if taken without consultation with your physician, can cause kidney damage. It is frequently combinations of medication, both prescribed and over the counter that cause kidney damage.
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